Flucloxacillin in Cellulitis: A randomised controlled trial comparing continuous infusion to bolus dosing for uncomplicated cellulitis.
In an adult population with uncomplicated cellulitis presenting to an Emergency Department is flucloxacillin delivered by infusion comparable to bolus dosing for nursing workload and patient discharge at 24 hours?
Royal Brisbane & Women's Hospital
200 participants
Oct 15, 2010
Interventional
Conditions
Summary
The purpose of this study is to test the hypothesis that by managing Emergency Department patients with uncomplicated cellulitis in a short stay unit with a continuous 24 hour infusion of 8g of intravenous flucloxacillin as opposed to the current standard treatment of four 2g intravenous blouses administered every six hours for 24 hours, significant nursing time and resources would be saved with there being no decrease in the clinical or microbiological cure rate of the cellulitis.
Eligibility
Inclusion Criteria1
- Patients with cellulitis felt to be clinically suitable for management in an Emergency Department Short Stay Unit.
Exclusion Criteria7
- Abbreviated Mortality in Emergency Department Sepsis Score >4
- Physician intends to treat with other than Flucloxacillin 2G Intravenously four times daily
- Patient has any of the following comorbidities:
- Diabetes Mellitus
- Chronic Systemic Steroid Use
- Immunosuppression
- Patient will not be contactable by telephone for next 31 days
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Interventions
Efficacy of 8g Flucloxacillin administered continuously via infusion over 24 hours
Locations(1)
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ACTRN12610000682044