Not Yet RecruitingPhase 3ACTRN12610000713099

Mechanism of cardiovascular benefits of omega-3 fatty acids in hypertensive and normotensive subjects

Double-blinded, placebo controlled investigation of the cardiovascular benefits of omega-3 fatty acids in hypertensive and normotensive subjects

Sponsor

University of the Sunshine Coast

Enrollment

140 participants

Start Date

Sep 6, 2010

Study Type

Interventional

Conditions

Hypertensive men and women

Summary

This study is testing the hypothesis that improvements in cardiovascular health with omega-3 fatty acid supplements are attributed to improvements in vascular function.

Eligibility

Sex: Both males and femalesMin Age: 30 YearssMax Age: 85 Yearss

Plain Language Summary

Simplified for easier understanding

This study looks at how omega-3 fatty acids (fish oil) affect the heart and blood vessels in people with normal or mildly high blood pressure. You must be aged 30 to 85 and eat no more than 2 oily fish meals per week. People taking blood pressure medication, on special diets, or who are pregnant cannot participate.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Normotensive and Hypertensive subjects will receive 4x1 g placebo capsules/day (Sunola oil) for 3 weeks. Subjects will then be randomised to receive either 4x1g fish oil capsules/day (Blackmores Omeg

Normotensive and Hypertensive subjects will receive 4x1 g placebo capsules/day (Sunola oil) for 3 weeks. Subjects will then be randomised to receive either 4x1g fish oil capsules/day (Blackmores Omega Heart, Blackmores Ltd, Australia) containing 2.52 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), or 4x1g placebo capsules/day for 12 weeks. A final 3 week washout phase will follow in which subjects cease taking the capsules. Subjects will record daily blood pressure (BP) at home using an automated BP device for the 18 week trial. Fasted blood samples will be taken every three weeks, commencing at week 0. Subjects will undergo a cold pressor test, a hand grip test, and reactive hyperaemic response with measurements of BP, blood flow and heart rate variability at weeks 1, 3 and then at 3 weekly intervals.

Locations(1)

Australia

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ACTRN12610000713099