Intranasal oxytocin for the treatment of cannabis and alcohol dependence

This study is testing whether a nasal spray form of oxytocin — a hormone sometimes called the 'bonding hormone' — can help people who are dependent on cannabis and/or alcohol reduce their use and manage withdrawal symptoms. Oxytocin may help reduce cravings and the difficulty of withdrawing from these substances. Participants will receive either the oxytocin spray or a placebo and be followed up one month later. You may be eligible if: - You are between 18 and 80 years old - You meet the clinical criteria for cannabis and/or alcohol dependence You may NOT be eligible if: - You have epilepsy - You have severe depression with suicidal thoughts or actions - You are dependent on other drugs (besides nicotine, cannabis, or alcohol) - You have significant heart, kidney, or liver disease - You are currently pregnant - You have chronic nasal problems (obstruction, discharge, or bleeding) Talk to your doctor about whether this trial might be right for you.