Effects of perioperative Recombinant Human Erythropoietin administration on proinflammatory cascade following breast cancer surgery.
A double blinded, randomized, placebo controlled study on the effects of Recombinant Human Erythropoietin on proinflammatory cytokines expression following modified radical mastectomy in females with breast cancer stage II/III
University Hospital of Ioannina
22 participants
Feb 28, 2000
Interventional
Conditions
Summary
It is known that erythropoetin has been used in clinical practice to minimize blood transfusions in the surgical patients. The aim of this study was to evaluate the impact of erythropoetin in the immune system of breast cancer patients stage II/III in the context of the pleotropic properties of the drug that have been recently discovered. Our hypothesis was that by ameliorating the immune response, the drug may have some effect on tumor recurrence.
Eligibility
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Interventions
Study group: subcutaneous perioperative administration of Recombinant Human Erythropoietin (10000IU/day, subcutaneously) for 9 preoperative and 2 postoperative days Also all patients recieved oral iron supplementation (200mg/day) for 9 preoperative and 2 postoperative days
Locations(1)
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ACTRN12610000813088