Single Patient Multiple Cross-Over Trials To Determine The Efficacy Of Pilocarpine In Relieving Dry Mouth In Patients With Cancer

Active pilocarpine 4% (40 mg/ml) drops; Pilcoarpine (po) 2-3 drops 3 times daily (4-6 mg three times daily) with meals in raspberry water delivered as a mouth dropper. Rasberry water is combined with the active treatment in order to simulate the taste of the placebo, rasberry water. This is to ensure the patient remains blind to the treatment. The active treatment will be administered in a cycle pair. A cycle pair is a course of treatment over 6 days. For 3 consecutive days, the patient will take the active treatment followed by 3 days on placebo. The duration of the trial will consist of 3 cycle pairs taking place over 18 days. A follow-up on day 19 by the patients physician will then take place. A washout period will be instigated on the first day of each cycle. On that day, no measurements will be taken.