CompletedPhase 2ACTRN12610000874011

The use of 5% tea tree oil for the prevention of infections in renal dialysis patients

An investigator blinded controlled study of the nasal application of 5% tea tree oil (TTO) versus mupirocin for the prevention of catheter-associated infections in renal dialysis patients


Sponsor

The University of Western Australia

Enrollment

100 participants

Start Date

Aug 1, 2010

Study Type

Interventional

Conditions

Summary

"Golden staph" is carried in the noses of 20-50% of people at any given time. People who are having renal dialysis and who carry 'golden staph' in their nose are at a higher risk of infection than those who do not. To minimise this risk renal dialysis patients are given prolonged treatment with mupirocin cream which is applied in their nostrils to kill 'golden staph'. This has lead to resistant strains of 'golden staph' that are not killed by the mupirocin treatment. Tea tree oil ointment has been used to kill 'golden staph' in people's noses and prolonged exposure to tea tree oil has not lead to development of resistance in bacteria. It also kills a wide range of bacteria and fungi, not just 'golden staph and so we believe that tea tree oil would be at least as good as mupirocin at protecting renal patients from infection. So this trial is looking at the use of tea tree oil and comparing it to the use of mupirocin in protecting renal dialysis patients from infection with 'golden staph'.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether applying tea tree oil can help prevent infections in kidney dialysis patients. It is open to adults aged 18 and older with end-stage kidney disease who are on or about to start dialysis and do not have a known allergy to tea tree oil.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Use of 5% tea tree oil ointment as a nasal treatment instead of 2% mupirocin cream to eradicate nasal carriage of Staphylococcus aureus in renal dialysis patients. The mode of administration is 0.25

Use of 5% tea tree oil ointment as a nasal treatment instead of 2% mupirocin cream to eradicate nasal carriage of Staphylococcus aureus in renal dialysis patients. The mode of administration is 0.25g per nostril applied topically inside nostrils for both 5% tea tree oil ointment and 2% mupirocin cream and treatment time is daily for the first 5 days and then weekly for 26 weeks.


Locations(1)

Australia

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ACTRN12610000874011