The use of 5% tea tree oil for the prevention of infections in renal dialysis patients
An investigator blinded controlled study of the nasal application of 5% tea tree oil (TTO) versus mupirocin for the prevention of catheter-associated infections in renal dialysis patients
The University of Western Australia
100 participants
Aug 1, 2010
Interventional
Conditions
Summary
"Golden staph" is carried in the noses of 20-50% of people at any given time. People who are having renal dialysis and who carry 'golden staph' in their nose are at a higher risk of infection than those who do not. To minimise this risk renal dialysis patients are given prolonged treatment with mupirocin cream which is applied in their nostrils to kill 'golden staph'. This has lead to resistant strains of 'golden staph' that are not killed by the mupirocin treatment. Tea tree oil ointment has been used to kill 'golden staph' in people's noses and prolonged exposure to tea tree oil has not lead to development of resistance in bacteria. It also kills a wide range of bacteria and fungi, not just 'golden staph and so we believe that tea tree oil would be at least as good as mupirocin at protecting renal patients from infection. So this trial is looking at the use of tea tree oil and comparing it to the use of mupirocin in protecting renal dialysis patients from infection with 'golden staph'.
Eligibility
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Interventions
Use of 5% tea tree oil ointment as a nasal treatment instead of 2% mupirocin cream to eradicate nasal carriage of Staphylococcus aureus in renal dialysis patients. The mode of administration is 0.25g per nostril applied topically inside nostrils for both 5% tea tree oil ointment and 2% mupirocin cream and treatment time is daily for the first 5 days and then weekly for 26 weeks.
Locations(1)
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ACTRN12610000874011