Coherex WaveCrest Left Atrial Appendage Occlusion Study A multi-center study to evaluate the safety and efficacy of the Coherex WaveCrest Left Atrial Appendage Occlusion System

This study is testing a device called the Coherex WaveCrest that is designed to plug (occlude) a small pouch in the heart called the left atrial appendage. In people with atrial fibrillation (an irregular heartbeat), blood clots can form in this pouch and cause strokes. The device is an alternative to blood-thinning medications for people who cannot take them safely. Researchers will check that the device is safe and effective at sealing the appendage. You may be eligible if: - You are 18 years of age or older - You have been diagnosed with non-valvular atrial fibrillation (paroxysmal, persistent, or permanent) - You need long-term blood thinning treatment, OR you cannot safely take blood thinners - You do not have another condition that requires long-term blood thinners - Your CHADS stroke risk score equals 1 - You are willing to attend all required follow-up visits You may NOT be eligible if: - You have had a stroke or TIA (mini-stroke) in the past 30 days - You had a heart attack in the past 3 months - You have severe heart failure (Class IV) - You have a blood clot or cardiac tumor in the heart - You have a mechanical heart valve or have had a heart transplant - You are pregnant or planning to become pregnant - Your resting heart rate is above 110 beats per minute Talk to your doctor about whether this trial might be right for you.