CompletedPhase 4ACTRN12610001016022

Dexamethasone as a lower limb block adjuvant for foot and ankle surgery

Dexamethasone as a lower limb block adjuvant for foot and ankle surgery to compare duration of pain relief post operatively


Sponsor

Dr Michael Fredrickson

Enrollment

120 participants

Start Date

Nov 23, 2010

Study Type

Interventional

Conditions

Summary

Epidural dexamethasone has been used for many years as a treatment for lower back pain and more recently for postoperative analgesia. Favourable results have also been demonstrated when dexamethasone is added to bupivacaine for interscalene nerve block: the time to first onset of operative site pain increased from 12 to 20 hours. However, perineural dexamethasone has not been studied when added to bupivacaine for lower limb peripheral nerve block. The main limitation of the lower limb block for postoperative analgesia is its limited duration of effect; therefore, any therapeutic intervention effective in prolonging lower limb block duration has clinical value. The primary aim of this study therefore is to test the hypothesis that the addition of dexamethasone 8 mg to 30 mL bupivacaine 0.5% administered via lower limb block will prolong the time to first pain after foot and ankle surgery conducted under general anaesthesia.


Eligibility

Sex: Both males and femalesMin Age: 16 YearssMax Age: 80 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether adding dexamethasone to a nerve block can improve pain relief after foot or ankle surgery. It is for patients aged 16 to 80 who are having foot or ankle surgery and do not have nerve damage or allergies to local anesthetics.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Dexamethasone Group A single operator will place all blocks in the operating room. Patients will be premedicated with oral acetaminophen 1 g one hour before surgery. Intravenous midazolam 2 mg, alfen

Dexamethasone Group A single operator will place all blocks in the operating room. Patients will be premedicated with oral acetaminophen 1 g one hour before surgery. Intravenous midazolam 2 mg, alfentanil 0.5 mg will be administered 5 min prior the establishment of general anaesthesia. A standardised lower limb block will be administered using standard landmarks. Patients will receive (using a computerised random number generator) 30 mL of bupivacaine 0.5% to which 2 ml of dexamethasone 8 mg will be added. Patients will receive a 2 ml intramuscular injection of 0.9% saline.


Locations(1)

Auckland, New Zealand

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ACTRN12610001016022