RecruitingPhase 4ACTRN12610001017011
Investigation Into The Efficacy And Safety Of Sildenafil Versus Natural Progesterone For prevention Of Preterm Labour A randomized controlled study
Investigation Into The Efficacy And Safety Of Sildenafil Versus Natural Progesterone For prevention Of Preterm Labour A randomized controlled study
Sponsor
waleed elkhayat
Enrollment
60 participants
Start Date
Jun 1, 2010
Study Type
Interventional
Conditions
Summary
to use sildenafil to prevent preterm labour with high effeicacy & most safe , as it is an excellent muscle relaxant.
Eligibility
Sex: FemalesMin Age: 18 YearssMax Age: 40 Yearss
Inclusion Criteria2
- pregnant woman 18-24 weeks gestation , the gestational age was estimated by the date of the last menstrual period and confirmed by fetal growth measurement with ultrasound.
- Asymptomatic pregnant woman with a history of at least 1 previous preterm labour( between 20 and 36 weeks plus 6 days gestational age).
Exclusion Criteria10
- multiple pregnancy
- premature rupture of membrane
- vaginal bleeding
- diabetes
- history of cardiovascular disease
- herniation of the membrane beyond the external cervical os
- congenital anomalies of the fetus
- any fetal or maternal contraindication to tocolysis(fetal asphyxia, intrauterine growth restriction, pre-ecalmpsia , clinical diagnosis of abruption placentae, placenta previa)
- active liver disease, renal impairment.
- recent stroke or heart attack.
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Interventions
sildenafil 100 mg vaginally every 12 hours , for 10 weeks prior to scheduled labour
sildenafil 100 mg vaginally every 12 hours , for 10 weeks prior to scheduled labour
Locations(1)
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ACTRN12610001017011