RecruitingACTRN12610001075077

Cardiac function and cerebral blood flow in the beachchair surgical patient.

The effect of vasopressor therapy with phenylepherine infusion versus a placebo saline infusion on cardiac function and cerebral blood flow in the beachchair surgical patient.


Sponsor

The Avenue Hospital

Enrollment

34 participants

Start Date

Jun 1, 2010

Study Type

Interventional

Conditions

Summary

During shoulder surgery patients are commonly positioned into an upright sitting position for optimal access to the shoulder joint. In some patients blood pressure may decrease and a concern of the anaesthetist is whether sufficient blood reaches the brain during such surgery. Even though this can be routinely treated with cardiac drugs, the exact effect of this treatment on the brain is unknown. This study plans to investigate the changes in cardiac function and flow to the brain when patients are anaesthetised and placed upright. The surgery will be performed using the anaesthetic technique that we use for the majority of the surgeon’s cases. The patient will receive a nerve block that will anaesthetise the arm receiving surgery. This will be combined with a general anaesthetic. Special monitoring of the heart and blood flow using sound waves, and brain function using reflected light waves will be used. These techniques are both non-invasive and present no harm to the patient. The study will investigate whether the administration of medication to gently increase blood pressure has an effect on hypotension and blood flow to the brain. In addition postoperative cognitive recovery will be assessed via a questionaire. By agreeing to the study patients will give us permission to make these extra measurements during anaesthesia, in order to understand whether we are protecting the brain during surgery.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 80 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at what happens to blood flow in the brain and heart function when patients are placed in an upright sitting position (beach chair position) during shoulder surgery under general anesthesia. Researchers want to know if the medications used to maintain blood pressure during surgery adequately protect the brain from reduced blood flow. Participants will also be assessed for cognitive (thinking) changes after surgery. You may be eligible if: - You are between 18 and 80 years old - You are scheduled for shoulder surgery in the beach chair position - You are able to give informed consent You may NOT be eligible if: - You have had a previous stroke or cerebrovascular event - You have significant heart disease (including a pacemaker) or significant lung or breathing problems - You have a contraindication to the nerve block used (interscalene block) - Your BMI is above 35 - You do not have an adequate understanding of English Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

This study will investigate the effects of vasopressor therapy on cerebral blood flow and oxygenation, in the beach chair position during shoulder surgery. Following interscalene brachial plexus anaes

This study will investigate the effects of vasopressor therapy on cerebral blood flow and oxygenation, in the beach chair position during shoulder surgery. Following interscalene brachial plexus anaesthesia with 20-20 ml ropivicaine 0.75%, general anaesthesia will be induced with propofol 50-200mg and maintained on sevoflurane 2-3%. Phenylephrine infusion 0.15 - 0.5 microgram/kg/min titrated to increase mean arterial pressure by 20 % versus saline infusion. Infusion is maintained whilst patient placed into beachchair position for surgery. The duration of intervention is 1 hour.


Locations(1)

Australia

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ACTRN12610001075077