Effects of dipeptidyl peptidase IV (DPP-IV) inhibition (vildagliptin) on plasma concentrations of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) during intraduodenal fat infusion.
Does dipeptidyl peptidase IV (DPP-IV) inhibition (vildagliptin) potentiate the effects of intraduodenal fat on glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), and thereby reduce energy intake and postprandial triglycerides, and increase energy expenditure and fat oxidation in healthy lean males?
Royal Adelaide Hospital
16 participants
Jan 15, 2011
Interventional
Conditions
Summary
When we ingest a meal a number of hormones are released from the small intestine. These hormones play an important role in regulating the motor function of the gut, the levels of sugar and fat in the blood, and the rate at which the body uses energy. The effects of these hormones on these factors may, however, be limited by the fact that they undergo rapid degradation by an enzyme in the blood. There is a new class of drugs that act by inhibiting this enzyme, and as a result, these drugs improve blood glucose levels in type 2 diabetic patients by increasing active concentrations of these hormones following glucose ingestion. It is currently unclear how these drugs will influence concentrations of these gastrointestinal peptides following fat intake, and that is what this study is designed to investigate.
Eligibility
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Interventions
Following enrolment, each volunteer will be studied on 2 occasions, in a crossover design, with a double-blind, randomized order, to evaluate the effects of intraduodenal infusion of fat (10 % Intralipid (Fresenius Kabi Pty. Ltd., Hornsby, NSW, Australia), 2.9 kcal/min, infusion rate: 2.6 ml/min): (i) following oral ingestion of 1 * Galvus tablet (50 mg vildagliptin) (ii) following oral ingestion of 1 * matched placebo tablet on blood glucose, plasma insulin, glucagon, GLP-1 (total and active), GIP (total and active), PYY (total and active) concentrations, appetite perceptions and energy intake, triglyceride and free fatty acid concentrations, energy expenditure and fat oxidation. A 1 week break will be required between each of the two study days.
Locations(1)
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ACTRN12610001104044