Inter-ethnic differences in tolerance of anti-cancer drugs in non-small cell lung cancer patients

Doctors have noticed that Asian and Caucasian patients with non-small cell lung cancer (a type of lung cancer) seem to have different side effects and tolerances when taking the same chemotherapy drugs. This study is trying to understand why. Researchers are comparing how patients from different ethnic backgrounds process the chemotherapy drugs carboplatin and paclitaxel. They are looking at differences in the immune system, nutrition levels, genetics, and other factors to see what might explain these differences. You may be eligible if: - You are 18 years or older - You identify as Asian or Caucasian - You have been diagnosed with advanced non-small cell lung cancer (confirmed by a tissue sample) - You are being treated with carboplatin and paclitaxel chemotherapy - Your overall health level is good enough to tolerate treatment (ECOG performance status 0–2) - Your blood counts and organ function are within acceptable ranges You may NOT be eligible if: - You need your chemotherapy dose adjusted for reasons other than standard protocols - You have active cancer spread to the brain - You have bone marrow involvement from the cancer - You have a serious active infection or autoimmune disease - You are on long-term steroids or immune-suppressing medications - You have had chemotherapy within the past 4 weeks - You have another active cancer - You are allergic to any of the chemotherapy drugs in this study Talk to your doctor about whether this trial might be right for you.