Fish Oil and Multivitamin Study in Healthy Adults.
An investigation of Omega-3 and Multivitamins on Mood, Cardiovascular health, Cognition in a healthy cohort of men and women aged 50 to 70 years of age.
Swisse Vitamins Pty Ltd
160 participants
Jan 25, 2010
Interventional
Conditions
Summary
In Australia, the population is ageing due to lower birth rates and increased life expectancy. The implication of this changing demographic means that the age group with the greatest needs will be the elderly. Research in this area includes studies assessing the efficacy of fish oils and multivitamins to improve memory and cognitive function in the elderly. Research is also focussing on the potential neuroprotective effects of these supplements to protect the elderly from more insidious cognitive decline, such as Alzeimer’s disease. The primary aim of the current study is to investigate whether supplementing diets with fish oils and multivitmains improve cognitive function in a healthy cohort of women and men aged 50 to 70 years of age. This research could potentially have significant bearing on the cognitive health of the elderly as well as the predicted economic burden in decades to come. Based on previous research, it is hypothesised that diets supplemented with a high dose of fish oil will improve cogntive performance namely spatial working memory performance and attentional processes. It is also anticipated that a high dose of fish oil compliemented with a multivitamin will provide additional benefits to cognitive performance as the multivitamins will limit oxidation of the Omega-3's once they have been ingested.
Eligibility
Plain Language Summary
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Interventions
The current study includes three treatment arms and one control arm. Participants were instructed to consume the supplements daily over a 4 month period. To implement the high and low dose fish oil conditions, the fish oil capsules were separated in morning and evening containers. 1) High dose fish oil and active multivitamin - Participants were instructed to consume 1 multivitamin capsule and 6 grams of fish oil daily. 2) Low dose fish oil and active multivitamin - Participants were instructed to consume 1 multivitamin and 6 grams of oil consisting of 3 grams of fish oil and 3 grams of sunola oil daily. 3) High dose fish oil and placebo multivitamin - Participants were instructed to consume 1 placebo multivitamin and 6 grams of fish oil daily. Composition of active fish oil and multivitamin. Active fish oil: Wild salmon Fish oil. The high dose fish oil condition contained 6 grams of fish oil equating to 480 mg of EPA and 480 mg of DHA daily. The low dose fish oil condition contained 3 grams of non active fish oil (sunola oil) and 3 grams of fish oil, equating to 240 mg of EPA and 240 mg of DHA daily. Active Multivitmin formulation: Retinyl Acetate 2500 IU d-Alpha Tocopheryl Acid Succinate 24.2IU Thiamine Hydrochloride 30 mg Riboflavin 30 mg Nicotinamide 20 mg Pantothenic Acid 64 mg Pyridoxine Hydrochloride 30mg Cyanocobalamin 115mg Cholecalciferol 200 Iu Vitamin H 150 mcg Folic Acid 500 mcg Phytomenadione 60 mcg Ascorbic acid 165 mg Citrus Bioflavonoids Extract 20 mg Calcium Orotate 100 mg Magnesium Aspartate Dihydrate 100 mg Selenomethionine 65 mcg Molybdenum Trioxide 67.5 mcg Chromium picolinate 50 mcg Manganese Amino Acid Chelate 30 mg Ferrous Fumarate 16.01 mg Copper Gluconate 8.57 mg Potassium Iodide 196 mcg Zinc Amino Acid Chelate 75 mcg Ubidecarenone 2 mg Vaccinium Macrocarpon 800 mg Silybum Marianum 1500 mg Turnera diffusa Leaf Ginkgo Biloba 1000 mg Scutellaria Lateriflora 50 mg Vitis Vinifera 1000 mg Cynara Scolymus 100 mg Urtica Dioica 100 mg Cimicifuga Racemosa 200 mg Tagetes Erecta 100 mg Curcuma Longa 100 mg Withania Somnifera 500 mg Crataegus monogyna Fruit 100 mg Silica Colloidal Anhydrous 20 mg Bacopa Monnieri 50 mg Lecithin Powder - Soy Phosphatidyl-serine Enriched Soy 10 mg Spearmint Oil 2 mg Vaccinium Myrtillus Fresh Fruit 100 mg
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ACTRN12611000094976