WithdrawnPhase 2ACTRN12611000118909

Does adjunctive therapy with Minocycline improve pain and opioid effectiveness in complex lower limb trauma? - A prospective randomised controlled trial.

Sponsor

Dr David Lindholm

Enrollment

90 participants

Start Date

Oct 1, 2013

Study Type

Interventional

Conditions

Neuropathic Pain in Complex Lower Limb Trauma Glial activation by opioids acting at TLR4 receptors in Complex Lower Limb Trauma.Opioid tolerance in Complex Lower Limb Trauma.

Summary

Patients with complex lower limb trauma experience severe pain. Opioids and inflammation activate glia which may increase the severity of pain experienced. Minocycline acts via inhibiting Toll Like Receptor 4 and may reduce pain severity if given early. This and drugs with similar effects at TLR4 receptors appear to work well in animal models of severe pain. Minocycline may also reduce opioid tolerance and opioid side effects particularly respiratory depression.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether adding the antibiotic minocycline to standard pain treatment can improve pain management and reduce the need for strong painkillers in adults aged 18-65 with serious lower leg injuries. It may offer a new approach to managing trauma-related pain.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Minocycline 100 mg Twice daily (bd) introduced as soon as possible following trauma to lower limbs continued for 1 month. Minocycline may reduce the need for opioids which are normally used to treat s

Locations(1)

VIC, Australia

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ACTRN12611000118909