RecruitingACTRN12611000189921

Corneal Collagen Cross-linking (CXL) as an adjunct in the treatment of Microbial Keratitis

In patients with microbial keratitis, is conventional treatment plus corneal collagen cross-linking (CXL) more effective than conventional treatment alone in terms of time to healing, visual results, and secondary interventions required?


Sponsor

Dr Laurence Sullivan

Enrollment

298 participants

Start Date

Aug 22, 2011

Study Type

Interventional

Conditions

Summary

Microbial keratitis is a significant cause of ocular morbidity and visual loss, as well as a significant health cost to the community. Ultraviolet light is known to be microbicidal. We think it is likely that the proposed treatment will lead to quicker recovery from this serious eye infection and better visual outcomes.


Eligibility

Sex: Both males and females

Plain Language Summary

Simplified for easier understanding

Microbial keratitis is a serious eye infection of the cornea (the clear front surface of the eye) that can cause significant vision loss if not treated quickly. This study is testing whether adding ultraviolet light treatment (corneal collagen cross-linking, or CXL) — which is known to kill bacteria and fungi — alongside standard antibiotic treatment speeds up recovery and leads to better vision outcomes for people with moderate to severe corneal infections. You may be eligible if: - You have a presumed or confirmed moderate-to-severe microbial infection of the cornea (microbial keratitis) You may NOT be eligible if: - You are pregnant - Your cornea is at risk of perforating (developing a hole) or has already perforated Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

riboflavin 0.1% indextran solution is applied to the cornea every 2 minutes for 30 minutes, and then ultraviolet A light at 365nm and 3 watts/cm2 exposure is applied for a further 30 minutes

riboflavin 0.1% indextran solution is applied to the cornea every 2 minutes for 30 minutes, and then ultraviolet A light at 365nm and 3 watts/cm2 exposure is applied for a further 30 minutes


Locations(1)

Australia

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ACTRN12611000189921