Corneal Collagen Cross-linking (CXL) as an adjunct in the treatment of Microbial Keratitis
In patients with microbial keratitis, is conventional treatment plus corneal collagen cross-linking (CXL) more effective than conventional treatment alone in terms of time to healing, visual results, and secondary interventions required?
Dr Laurence Sullivan
298 participants
Aug 22, 2011
Interventional
Conditions
Summary
Microbial keratitis is a significant cause of ocular morbidity and visual loss, as well as a significant health cost to the community. Ultraviolet light is known to be microbicidal. We think it is likely that the proposed treatment will lead to quicker recovery from this serious eye infection and better visual outcomes.
Eligibility
Inclusion Criteria1
- presumed or confirmed microbial keratitis of moderate severity or worse
Exclusion Criteria2
- Pregnancy
- impending or actual corneal perforation
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Interventions
riboflavin 0.1% indextran solution is applied to the cornea every 2 minutes for 30 minutes, and then ultraviolet A light at 365nm and 3 watts/cm2 exposure is applied for a further 30 minutes
Locations(1)
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ACTRN12611000189921