A study on the satiety effect of Caralluma fimbriata extract for people with Prader - Willi syndrome (PWS).”

This study is testing whether a natural supplement called Caralluma fimbriata (a type of cactus plant) can reduce hunger in children and teenagers with Prader-Willi syndrome (PWS). PWS is a genetic condition that causes a constant, severe feeling of hunger that is very difficult to control. This double-blind crossover study (where neither families nor researchers know who gets the real supplement versus a dummy pill) will test whether Caralluma fimbriata can safely reduce appetite signals in young people with PWS. You may be eligible if: - Your child is between 5 and 17 years old - Your child has a confirmed genetic diagnosis of Prader-Willi syndrome - Your child is in good general health with typical features of PWS - Your child is under constant adult supervision - English is spoken in the home You may NOT be eligible if: - Your child has diabetes (type 1 or 2) or glucose intolerance - Your child has chronic asthma, heart disease, liver or kidney problems, or severe sleep apnoea - Your child is on seizure medications, ADHD medications, antidepressants, or testosterone/oestrogen - Your child is in psychiatric care Talk to your doctor about whether this trial might be right for you.