ActivePhase 2Phase 3ACTRN12611000350921
The effects of memantine versus placebo on visual functions of patient with optic neuritis
In patients with optic neuritis, is Memantine as good as or better than placebo for improving visual functions?
Sponsor
Tehran University of Medical sciences
Enrollment
60 participants
Start Date
Apr 1, 2010
Study Type
Interventional
Conditions
Summary
Evaluation of the neuroprotective effect of Memantine in visual function of patients with optic neuritis. Our hypothesis was that Memantine helps for better improvement of visual function in acute optic neuritis.
Eligibility
Sex: Both males and femalesMin Age: 10 YearssMax Age: 50 Yearss
Inclusion Criteria1
- Isolated acute optic neuritis with duration of less than 8 days as patient declares
Exclusion Criteria3
- anti-convulsants, barbiturates, neuroleptics, Amantadine hydrochlorothiazids, digoxin and dextrometorphan (interacting with memantine)
- Pregnancy or nursing
- Renal disease
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Interventions
Memantine tablets for treatment group for 3 weeks orally(5mg/day for the first week and 10 mg/ day for the next two weeks)
Memantine tablets for treatment group for 3 weeks orally(5mg/day for the first week and 10 mg/ day for the next two weeks)
Locations(1)
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ACTRN12611000350921