RecruitingACTRN12611000583943

Dietary salt and blood vessel function

The effect of a high sodium meal versus a low sodium meal on acute blood vessel function in healthy volunteers: a randomised crossover trial


Sponsor

Commonwealth Scientific and Industrial Research Organisation (CSIRO): Food and Nutritional Science

Enrollment

16 participants

Start Date

Jun 6, 2011

Study Type

Interventional

Conditions

Summary

The purpose of the study is to see whether a salty meal (equivalent to about 3/4 teaspoon of table salt, the same amount found in a ham sandwich or a meal of bacon and eggs) causes levels of sodium (salt) in the blood to rise. We want to know this because high salt meals may have adverse effects on blood vessel function.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

This study investigates what happens to sodium (salt) levels in the blood shortly after eating a salty meal — similar to a ham sandwich or bacon and eggs. Researchers want to know if a single high-salt meal causes a temporary rise in blood sodium and whether that rise can affect the way your blood vessels work. Participants eat a controlled meal and have their blood tested and blood vessels measured before and after. You may be eligible if: - You are between 18 and 70 years of age - Your BMI is between 18.5 and 28 kg/m² - Your blood pressure is in the normal range (systolic under 130, diastolic under 90 mmHg) - Your weight has been stable for the past 6 months You may NOT be eligible if: - You have a known metabolic disease such as liver or kidney disease - You are being treated for high blood pressure - You have a history of heart disease or stroke - You are currently taking anti-inflammatory drugs, folate supplements, or systemic steroids - You have lost more than 5% of your body weight in the past 6 months Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

In a randomised cross-over design, participants will consume a test meal containing 65mmol of sodium or a low salt control meal containing 5mmol sodium on 2 separate study days with a 7 day washout pe

In a randomised cross-over design, participants will consume a test meal containing 65mmol of sodium or a low salt control meal containing 5mmol sodium on 2 separate study days with a 7 day washout period in between treatments. The test meal will comprise of 100ml of Reduced Salt tomato soup made up with 150mL water with 3.8g of added salt (65mmol NaCl sodium chloride). Participants are asked to consume the test meal over a 5 minute period.


Locations(1)

Australia

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ACTRN12611000583943


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