Hysterectomy or Uphold Uterine Conservation in women with apical prolapse – a Comparative Trial (HUUT)

This study compares two surgical approaches for women with pelvic organ prolapse — where the uterus and vaginal walls slip out of their normal position. One option is the traditional surgery that removes the uterus (vaginal hysterectomy). The other is a newer procedure using a synthetic mesh device called 'Uphold' that supports the vagina without removing the uterus. The study helps women and their surgeons understand which option works better and has fewer complications. You may be eligible if: - You are a woman 18 years of age or older - You have been diagnosed with pelvic organ prolapse at Stage 2 or above with uterine descent causing symptoms - You have been referred for surgical treatment You may NOT be eligible if: - You have unexplained abnormal menstrual or post-menopausal bleeding - You have an abnormal cervical smear result that has not been fully evaluated - You are not up to date with cervical screening - You have evidence of cancer of the uterus or cervix - You have not yet completed your family (you plan to have more children) - You have had previous synthetic mesh used for pelvic organ prolapse - You have a history of chronic pelvic pain - You are unwilling to undergo hysterectomy if randomly assigned to that group Talk to your doctor about whether this trial might be right for you.