Administration of pantoprazole and its effects on gastric PH,inflammatory & anti inflammatory factors in critically ill patients.
A Comparative study of bolus & Continuous administration of pantoprazole on gastric PH and its effect on inflammatory & anti inflammatory cytokines(IL1,TNFa vs IL10,EGF) in critically ill patients.
Tehran university of medical sciences
24 participants
Nov 10, 2010
Interventional
Conditions
Summary
Cytokines have some roles in stress related mucosal damage (SRMD),some studies mentioned probable anti inflamatory effects of proton pump inhibitors(PPIs). The primary purpose of this study is to find that if PPIs in critically ill patients can reduce inflamatory factors secreted in gastric juice in addition to increase the gastric pH?
Eligibility
Inclusion Criteria8
- -Age>18
- -Clinical need for a nasogastric tube
- -Expectation of 48 hrs of “nothing by mouth” status
- -Baseline gastric pH <3.5
- -High risk patients for stress ulcer(one of these risk
- factors)
- patients with Coagulopathy disorders.
- Ventilator dependant patients, shock, Respiratory failure, trauma
Exclusion Criteria7
- -History of peptic ulcer disease
- -Patients with zollinger Ellison
- -Recipients of H2 blockers & NSAIDS
- -Tube feeding
- -Creatinine>2 or Creatinine > %25 increase in base line
- -Abnormal LFT (3 times>base line)
- - Renal failure
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Arm 1: Critically ill patients with gastric pH below 3,bolus Pantoprazole(80 mg/day,48 hours) Arm 2:Critically ill patients with gastric pH below 3, continuous infusion Pantoprazole(80mg/day,48 hours) Arm3:Critically ill patients with gastric pH below 3,continuous infusion Ranitidin(150mg/day,48hours) pH measure by a pH meter probe and litmus paper
Locations(1)
View Full Details on ANZCTR
For the most up-to-date information, visit the official listing.
ACTRN12611000647932