Efficacy of mulberry, red ginseng and banaba in the regulation of blood glucose and insulin responses in type 2 diabetes
A six-month supplementation of mulberry, Korean red ginseng and banaba decreases biomarkers of systemic low grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes
Sookmyung Women's University
94 participants
Mar 1, 2007
Interventional
Conditions
Summary
To evaluate the long-term efficacy and safety of traditionally used anti-diabetic herbs in controlling blood glucose homeostasis and low grade inflammation, a six month clinical trial was performed with red ginseng roots, mulberry leaf water extract, and banaba leaf water extract in subjects with impaired glucose tolerance or mild cases of T2D.
Eligibility
Inclusion Criteria4
- Subjects diagnosed with the impaired glucose tolerence
- Subjects diagnosed with type 2 diabetes taking one or the combination of following mediations and have not changed the prescription for at least two months.
- Mediations: sulfonylurea, biguanide, alpha-gludosidase
- Subjects with BMI over 20kg/m2, non-pregnant who has not taken herbs at least for last 3 months
Exclusion Criteria3
- Patients taking insulin or medications other than sulfonylurea, biguanide or alpha-glucosidase during last 2 months
- Individuals with chronic liver diseases, advanced kidney di se ases, atherosclerosis, myocardial infarction, pulmonary diseases, gastrointestinal diseases, hematological diseases and cancer
- Individuals receiving or have received pharmacological doses of steroids and/or participating weight reduction programs
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Interventions
6g/day (2g x 3 times a day) of 1:1:1 mixture of the herbal preparation for 24 weeks. (6g/day of herabl preparation was consisted of 2g/day of Korean red ginseng, 2g/day of Muberry leaf, 2g/day of banaba leaf) Speficification of herbal preparation: Korean red ginseng (Panax ginseng C.A. Mayer) powder, mulberry (Morus alba L.) leaf water extract powder, and banaba (Lagerstroemia speciosa L.) leaf water extract powder The mode of administration: oral capsule
Locations(1)
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ACTRN12611000655943