RecruitingACTRN12611000777998

Results of serial assessment of eye movement recovery in patients with acute vertigo (labyrinthitis)

Serial assessment of the hypoactive Vestibular ocular reflex in patients with acute labyrinthine dysfunction

Sponsor

Capital and Coast health

Enrollment

12 participants

Start Date

Aug 1, 2011

Study Type

Observational

Conditions

Acute labyrinthitis

Summary

The primary purpose of the study is to observe the compensatory strategies that the brain uses to recover from acute labyrinthitis. It is proposed that in patients with a partial labyrinthitis there may be a complete and early recovery of their eye movements generated by the inner ear. That is, the normal eye velocity generated by balance receptors in the inner ear should match the head velocity signal in a short period of time of seven days. Secondly it is proposed that the compensatory brain mechanisms used following acute labyrinthitis with rapid catch up eye movements (covert saccades) will occur within the first 24-48 hours of presentation.

Eligibility

Sex: Both males and femalesMin Age: 10 Yearss

Plain Language Summary

Simplified for easier understanding

This study is watching how the brain recovers after a sudden attack of labyrinthitis — a condition where the inner ear becomes inflamed, causing severe dizziness. Researchers will use a special eye-tracking camera to measure how the brain adapts and uses different strategies to compensate for the damaged inner ear over the course of several days. You may be eligible if: - You have been diagnosed with acute labyrinthitis (sudden, severe dizziness from inner ear inflammation) - You are 10 years or older You may NOT be eligible if: - You are too unwell to have the eye-tracking assessment performed Talk to your doctor about whether this trial might be right for you.

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Interventions

Measurement of the hypoactive vestibular ocular reflex (VOR) by videooculography Patients with clinical features of acute labyrinthitis will be seen in casualty within 24hrs of their symptom onset

Measurement of the hypoactive vestibular ocular reflex (VOR) by videooculography Patients with clinical features of acute labyrinthitis will be seen in casualty within 24hrs of their symptom onset of acute vertigo. The head impulse test measures the eye movement response of a hypoactive VOR to a high acceleration head impulse when the examiner moves the subjects head with brief random head thrusts in the angular plane. It is hoped that approximately 12 random head impulse tests will be able to be assessed to the ipsilateral and contralateral side, depending on patient compliance and acceptability. The abnormal VOR will be monitored serially with videooculography with repeat testing in a 20 minute session to assess recovery on six occasions over a period of up to 3 months.

Locations(1)

New Zealand

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ACTRN12611000777998