ActivePhase 4ACTRN12611000840987

A randomized clinical trial of adefovir to treat patients with hepatitis B-related hepatocellular carcinoma after radical tumor resection

a randomized clinical trial to study whether adefovir can improve the prognosis of HCC patients with HBV-DNA>=10000 copies/ml

Sponsor

Eastern hepatobiliary hospital

Enrollment

200 participants

Start Date

May 1, 2007

Study Type

Interventional

Conditions

whether adefovir can prolong the disease-free survival and overall survival of hepatocellular carcinoma patients with HBV-DNA >=10000 copies/ml

Summary

The purpose of our study is to see whether anti-virus drugs can improve the prognosis of liver cancer and reduce the viral reactivity. We supposed that adefovir can reduce the tumor recurrence and viral reactivity, prolong the overall survival of patients.

Eligibility

Sex: Both males and femalesMin Age: 16 YearssMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

This trial tests whether the antiviral drug adefovir can benefit patients who have had liver cancer (hepatocellular carcinoma) linked to hepatitis B after their tumour has been surgically removed. Eligible patients are aged 16-70, test positive for hepatitis B with high viral load, and had early-to-intermediate stage cancer.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

we give adefovir 10mg oral tablet, once a day to patients in treatment group.Overall duration of antivirus treatment is according to the guideline of chronic hepatitis B. The indicatons to stop antivirus treatment are as follows:1.to the patients with HBeAg(+), they should take medicine for 6-12 months after HBeAg(+) becoming HBeAg(-) and then can stop the antivirus treatment;2.to the patients with HBeAg(-), when HBV-DNA is undetectable for three times with a interval of 6 months,they can choose to stop treatment;3.to cirrhosis patients, we recommend taking antivirus treatment for whole life.

Locations(1)

Shanghai City, China

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ACTRN12611000840987