RecruitingACTRN12611000856910

The effect of remote ischaemic preconditioning on the immune response in healthy volunteers

A paired-analysis trial investigating the effect of remote ischaemic preconditioning compared with no remote ischaemic preconditioning on inflammatory cytokine production and leukocyte function in healthy volunteers

Sponsor

Jenni Williams

Enrollment

10 participants

Start Date

Sep 1, 2011

Study Type

Interventional

Conditions

The intervention is primarily intended for use in cardiac surgery patients

Summary

There is evidence that remote ischaemic preconditioning (RIPC) protects organs from the effects of decreased blood supply during procedures such as heart surgery. Currently it is not known how this protection occurs, but it appears that RIPC may affect inflammation. This study will investigate the effects of RIPC on the immune system in healthy volunteers. The RIPC takes 30 minutes in total and involves inflation of a blood-pressure cuff on the upper arm for five minutes, temporarily preventing blood flow, followed by deflation for five minutes. This process is repeated three times. Participants will undergo a control session where a blood pressure cuff will be placed on the upper arm for 30 minutes without inflation. Seven days later a treatment session will take place where the blood pressure cuff is placed on the same arm and RIPC is performed. At each of these sessions samples of blood will be collected prior to placement of the blood pressure cuff, and at 20 minutes, 1 hour and 4 hours following. Blood will be analysed by looking for changes in immune cells and markers of inflammation.

Eligibility

Sex: MalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is investigating what happens to the immune system when a technique called remote ischaemic preconditioning (RIPC) is applied. RIPC involves briefly squeezing off blood flow to the arm (using a blood pressure cuff) several times for 5 minutes at a time. This simple procedure appears to protect the heart and other organs during major surgery, but researchers don't yet fully understand how it works. Healthy male volunteers will have blood samples taken before and after the procedure. You may be eligible if: - You are a healthy adult male - You have received a tetanus vaccine or booster within the last 10 years You may NOT be eligible if: - You have peripheral vascular disease (poor circulation in the limbs) - You are a smoker - You take regular medications - You have had an illness in the week before the study visits Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

A blood pressure cuff will be placed on the non-dominant upper arm and inflated to 200 mmHg for five minutes, then deflated for five minutes. This cycle will be repeated three times, taking a total of

Locations(1)

New Zealand

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ACTRN12611000856910