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CompletedPhase 4ACTRN12611000914965

The effect of routine reversal of neuromuscular blockade on surgical conditions for thyroid surgery

The effect of routine reversal using neostigmine, of neuromuscular blockade, on neuromuscular monitoring of the laryngeal nerve during thyroid surgery- a double blinded randomised control trial

Sponsor

Emma Boden

Enrollment

50 participants

Start Date

Aug 30, 2011

Study Type

Interventional

Conditions

Reversal of neuromuscular blockade during thyroid surgery

Summary

Participants will receive a standard anaesthetic with- propofol induction, remifentanil induction, 2x ED 95 (intubating conditions) atracurium 0.4mg/km, sevoflurane, dexamethasone and cefazolin. At 30 mins post induction patients will either get neostigmine/glycopyrrolate injection or saline injection prepared by an independent person, given by anaesthetist. Then the surgeon will determine, using the NIM stimulator whether the reversal of neuromuscular blockade is adequate.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 100 Yearss

Inclusion Criteria1

  • Thyroid surgery at Peninsula Health

Exclusion Criteria4

  • Allergy to atracurium
  • Musculoskeletal abnormality
  • Surgeon not using NIM stimulation intraoperatively
  • Recurrent laryngeal nerve injury/abnormality

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Interventions

Atracurium 0.4mg/kg given as an intubating dose, given intravenously as a bolus, then reversal at 30 mins with neostigmine 2.5mg and glycopyrrolate 0.4mg, intravenously as a bolus, if in the study arm

Atracurium 0.4mg/kg given as an intubating dose, given intravenously as a bolus, then reversal at 30 mins with neostigmine 2.5mg and glycopyrrolate 0.4mg, intravenously as a bolus, if in the study arm

Locations(1)

Australia

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ACTRN12611000914965