Can certain anaesthesia medications & techniques provide additional benefits after cancer surgery apart from pain relief and speed of recovery from that surgery (LIPO trial - Lignocaine infusion given peri-operatively)
Can anaesthetic technique in the form of peri-operative lignocaine infusion to blunt surgical stress response have additional benefits in long term outcome following primary cancer surgery
Palmerston North Hospital
600 participants
Oct 1, 2011
Interventional
Conditions
Eligibility
Inclusion Criteria2
- Non metastatic cancer requiring primary surgery:
- Colectomy, nephrectomy, prostatectomy, hysterectomy, melanoma excision, mastectomy, cystectomy
Exclusion Criteria7
- Metastases
- ASA 4 and above
- Diabetes
- Concurrent pre-operative opioid analgesic use
- Anti arrythmic drugs, arrythmogenic conditions
- Hepatic or renal impairment
- Pregnancy
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Interventions
Intra-operative lignocaine infusion. Replica of methodology from existing study, specifically Kuo et al, British Journal of Anaesthesia, 97 (5): 640–6 (2006): 2mg/kg over 15 mins, followed by 3mg/kg/hr IV. Continued intra-op and 30 mins post op. Intraoperative top-up fentanyl and post operative morphine patient controlled analgesia (PCA) if required. Additional resource [ANZCTR no: 12609001073291] & Annals of Surgery - Volume 246, Number 2, August 2007 page 192 - slight modification in methodology & dose
Locations(1)
View Full Details on ANZCTR
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ACTRN12611001005943