CompletedPhase 4ACTRN12611001018909

Tramadol administration in the critically ill

Pharmacokinetics of Subcutaneous Tramadol in Intensive Care Unit (ICU) step down patients

Sponsor

Guy Ludbrook

Enrollment

15 participants

Start Date

Apr 24, 2010

Study Type

Interventional

Conditions

Intensive Care Unit (ICU) Step Down patients who require patient controlled analgesia (PCA) Fentanyl as part of their management after trauma or surgery.

Summary

The study enabled dosing intervals, peak plasma concentration and rate of absorption of subcutaneous tramadol to be determined in Intensive Care Step Down Unit patients. It also permitted pharmacokinetic comparison with other subcutaneous opioids and assist in clinical decision-making about optimal opioid dosing regimens for moderate to severe acute pain.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 70 Yearss

Plain Language Summary

Simplified for easier understanding

This study examines how the pain medication tramadol is processed in the body when given to critically ill patients in the ICU who are stepping down from intensive care. It focuses on patients who need patient-controlled pain relief after trauma or surgery.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Tramadol Hydrochloride 50mg one injection only on study day. Administered over 1 minute subcutaneously

Locations(1)

Australia

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ACTRN12611001018909