The neuroendocrine and metabolic effects of oestrogens
The neuroendocrine and metabolic effects of oestrogens in healthy postmenopausal women and men the same age
Garvan Institute of Medical Research
20 participants
Aug 3, 2010
Interventional
Conditions
Summary
The purpose of this study is to understand how oestrogen controls the use of fat in the liver. The hypothesis is that oestrogen is required to prevent the accumulation of fat in the liver. The mechanism may be direct or mediated by other hormones such as growth hormone, which is regulated by oestrogen. We wish to study the effects of oestrogen compounds called Selective Oestrogen Receptor Modulators (tamoxifen) and a drug that prevents oestrogen production (letrozole) on the secretion of growth hormone from the special gland in brain and how they control the liver production and burning of fat in men and women. We wish to compare these effects with that of natural oestrogen itself in women.
Eligibility
Inclusion Criteria2
- Healthy postmenopausal women and men the same age
- BMI <25 kg/m2
Exclusion Criteria1
- History of liver, kidney diseases, cancer, diabetes, endocrine disorders, that are likely to interfere with the metabolism or excretion of the test medication.
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Interventions
1) Oestradiol 2 mg once daily orally for 2 weeks, followed by 4 weeks washout; 2) tamoxifen 20 mg once daily orally for 2 weeks, followed by 4 weeks washout; 3) letrozole 5 mg once daily orally for 2 weeks Women take all 3 treatments, men take only tamoxifen and letrozole.
Locations(1)
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ACTRN12611001093976