Treatment of chronic refractory urticaria with the medicine adalimumab

This study is testing whether a medication called adalimumab (which blocks an inflammatory chemical in the body) can help people with chronic hives (urticaria) that have not responded to other treatments. People with this condition can experience severe, disabling itching and hive outbreaks for months or years. Adalimumab targets the specific inflammation pathway involved. You may be eligible if: - You are between 18 and 67 years old - You have had chronic hives for more than 6 months with outbreaks nearly every other day - You have already tried high-dose antihistamines, prednisolone, and at least one other immunosuppressive drug for at least 3 months without enough relief You may NOT be eligible if: - You are pregnant or breastfeeding - You have diabetes, severe heart, kidney, or liver disease - You have a chronic infection - You have had a previous cancer (except non-melanoma skin cancer) - You have previously been treated with TNF-alpha inhibitors Talk to your doctor about whether this trial might be right for you.