CompletedPhase 3ACTRN12611001186943

Pregabalin and Speech Pathology Treatment for Chronic Cough

Pregabalin and Speech pathology Treatment for Idiopathic and Refractory Chronic Cough: A Randomised Treatment Controlled Trial with the primary outcomes of cough quality of life and objective cough frequency.

Sponsor

John Hunter Hospital

Enrollment

56 participants

Start Date

Mar 8, 2012

Study Type

Interventional

Conditions

Idiopathic and Refractory Chronic Cough

Summary

The primary purpose of this study is to investigate and trial a combined therapy of novel medication and speech pathology for a persistent cough that hasn't previously responded to typical medical treatment. We will compare this program to individual component treatments of medication or speech pathology with the aim of significantly reducing cough symptoms and cough severity. Our ultimate goal is to resolve the cough resulting in a significant improvement in patient quality of life.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 90 Yearss

Plain Language Summary

Simplified for easier understanding

This study evaluates whether pregabalin (a nerve pain medication) combined with speech pathology treatment can help adults aged 18 to 90 with chronic cough lasting 8 weeks or more that has not responded to standard medical treatment. Participants must be non-smokers or ex-smokers. People with productive cough, active respiratory disease, or untreated asthma are excluded.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Arm 1: Pregabalin, Up to 3x75 mg per day for 12 weeks, maximum dose 300 mg/day, oral route Arm 2: Speech pathology 4 step intervention for chronic cough, administered one on one with speech pathologi

Arm 1: Pregabalin, Up to 3x75 mg per day for 12 weeks, maximum dose 300 mg/day, oral route Arm 2: Speech pathology 4 step intervention for chronic cough, administered one on one with speech pathologist. Four steps include cough education, cough counselling, behavioural therapy such as swallowing technique, lifestyle intervention such as vocal hydration and at least one of these components will addressed at each visit depending on individual needs and understanding of the techniques by the participant. Each session will last for approximately 1 hour every 3 weeks for 12 weeks duration.

Locations(1)

NSW, Australia

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ACTRN12611001186943