Cholecalciferol Supplementation in Kidney Failure Study: Effect on Quality of Life and Muscle Strength
Richard Singer
88 participants
May 1, 2012
Interventional
Conditions
Summary
A one year trial comparing high dose nutritional vitamin D vs placebo that will primarily examine the effect on muscle strength and quality of life in patients with kidney failure.
Eligibility
Inclusion Criteria1
- Undergoing maintenance therapy with twice or thrice weekly conventional haemodialysis or receiving peritoneal dialysis. Clinically stable.
Exclusion Criteria1
- Baseline calcidiol level >50nmol/l, baseline hypercalcaemia, chronic granulomatous disorder
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Opaque capsule of oral Cholecalciferol 50000units/capsule given weekly for 12 weeks, followed by blinded calcidiol level and dose adjustment based on an algorithm designed to maintain blood calcidiol levels between 80-175nmol/l. Further blinded calcidiol level and dosage adjustment (if necessary) will occur at 24 weeks, with therapy continuing for 52 weeks. To avoid inadvertant unblinding, the number of capsules prescribed will be capped at 3 per week.
Locations(1)
View Full Details on ANZCTR
For the most up-to-date information, visit the official listing.
ACTRN12611001260910