Total and free serum Ropivacaine Concentrations for patients receiving Continuous Transversus Abdominis plane block for Postoperative analgesia after abdominal surgery: Pilot Study
Dr Sarika Kumar
15 participants
Oct 5, 2011
Interventional
Conditions
Summary
This is a pilot study looking into safety of giving bolus of ropivacaine followed by continous infusion for 48 hrs in Transversus Abdominis Plane Block. Safety of this regime will be established by serial blood samples to analyse toal & free ropivacaine concentration , Serail ECG 's looking into QTc interval & patient will be observed for sign & symptoms of Local anaesthetic toxicity
Eligibility
Inclusion Criteria4
- Elective/Emergency abdominal surgery
- Between 18 and 80 years of age
- ASA less than 4
- Adequate English language skills
Exclusion Criteria13
- Allergy to local anaesthetic
- Pt refusal
- ASA score > 4 (i.e 4,5)
- Pregnancy
- On regular opioid medication or any other medication for
- chronic pain management.
- Mental handicap or psychiatric condition precluding adequat
- communication.
- Patients taking ciprofloxacin & fluvoxamine (affects
- the metabolism of LA)
- Qt c interval > 0.45 sec in males and > 0.47 sec in females
- Drugs affecting Qtc interval e.g. Haloperidol, Amiodarone,
- Sotaol
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Interventions
Patients having mid line incision will have TAP block catheter towards the end of surgery. They will recieve 20 mls of 0.5% ropivacaine Bilateral (both sides) followed by continous infusion of 10mls/hr of 0.2% ropivacaine for 48hrs which will be started 30mins post 2nd bolus.
Locations(1)
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ACTRN12612000104853