A Randomized Trial Compared the Efficacy and Safety of Combined Use of Indocyanine Green Fluorescence and Methylene Blue Dye Versus Methylene Blue Dye alone for Sentinel Lymph Node Biopsy in Breast Cancer Patients

This trial compares two techniques for finding the sentinel lymph node (the first lymph node that breast cancer cells travel to) in women with early breast cancer. One technique uses blue dye alone; the other combines blue dye with a special fluorescent tracer called indocyanine green (ICG) that glows under infrared light. Finding the right lymph node is important to avoid removing too many, which can cause complications. The study measures how accurately each approach identifies the sentinel node. You may be eligible if: - You are female, aged 18 to 85 - You have been diagnosed with invasive breast cancer (tumour stage T1 to T3) - Your lymph nodes in the armpit are clinically normal (not enlarged) - Your cancer has not spread to distant parts of the body You may NOT be eligible if: - Your lymph nodes have already been confirmed as cancer-positive - You have a palpable (felt-by-hand) enlarged lymph node in the armpit - You have a history of severe allergy or iodine allergy - You have had previous surgery in the armpit area Talk to your doctor about whether this trial might be right for you.