Using ketamine (an anesthetic agent) with Propofol (a hypnotic agent commonly used during sedation) during visual examination of large intestine reduces propofol dosage improves the quality of sedation

Propofol is frequently used for sedation in endoscopy units. Usually opioids are used in combination to propofol in order to improve the quality of sedation. However combining opioids with propofol usually raises the incidance of adverse events such as apnea. Ketamine is usually used for sedation for invasive procedures outside the operating room especially in children. Its not preffered in adults for sedation because of agitation and hallucinations which can be prevented by using sedative or hypnotic agents. The most important advantage of using ketamine is that it does not supress the airway reflexes. Thus it can be hypotised that ketamine may be a better agent of choice than opioids to combine with propofol during sedation. The aim of this study is to investigate the effects of ketamine added to propofol in terms of propofol sparing effects, quality of sedation, adverse events and recovery times.