RecruitingPhase 3ACTRN12612000166875

Does progesterone support in luteal phase deficiency help subfertile couples achieve a pregnancy?

In women with unexplained subfertility and luteal phase deficiency, does luteal phase support with progesterone while using a fertility awareness-based charting method when compared to fertility awareness-based charting alone increase the likelihood of pregnancy?


Sponsor

Dr Luke McLindon

Enrollment

180 participants

Start Date

Feb 7, 2012

Study Type

Interventional

Conditions

Summary

This project aims to assess the effectiveness of progesterone as luteal phase support in unexplained subfertile women with a previously diagnosed luteal phase hormonal deficiency. All women will be instructed in a fertility awareness-based charting method (the Sympto-Thermal method). It is hypothesised that progesterone given as luteal phase support increases the likelihood of pregnancy in unexplained subfertile women with a recognised luteal phase hormonal defect.


Eligibility

Sex: FemalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether progesterone supplements taken in the second half of the menstrual cycle (luteal phase) can help women who have had trouble getting pregnant because of a hormonal problem called luteal phase deficiency. All women in the study will also learn a natural fertility awareness method called the Sympto-Thermal Method to track their cycles. Researchers hope this treatment will increase the chances of pregnancy. You may be eligible if: - You are a woman aged 18 or older - You have been diagnosed with a luteal phase hormonal defect based on hormone blood tests - You have been trying to get pregnant for 12 months without success, OR have had 3 or more miscarriages You may NOT be eligible if: - Your infertility is due to blocked tubes (confirmed by testing) - Your infertility is due to a male factor (abnormal sperm analysis) - You are exclusively breastfeeding - You are currently using contraception - You are currently pregnant - You are currently taking fertility medications or supplements (including Vitex agnus) Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

Progesterone pessaries (400 mg vaginally nightly) during each luteal phase (used for 10 consecutive nights), for up to 8 months/cycles. Formal instruction in the Sympto-Thermal Method is routinely

Progesterone pessaries (400 mg vaginally nightly) during each luteal phase (used for 10 consecutive nights), for up to 8 months/cycles. Formal instruction in the Sympto-Thermal Method is routinely provided.


Locations(1)

Australia

View Full Details on ANZCTR

For the most up-to-date information, visit the official listing.

Visit

ACTRN12612000166875


Related Trials