Does dietary fructose restriction improve cardio-metabolic health in obesity?
Does dietary fructose restriction improve plasma lipids, satiety hormones and inflammation in obesity?
The University of Newcastle
42 participants
Feb 29, 2012
Interventional
Conditions
Summary
Consumption of high fructose diets have been shown to contribute to the rising incidence of obesity worldwide. Increased fructose intake has been associated with many of the components of metabolic syndrome (insulin resistance, elevated waist circumference, dyslipidaemia, and hypertension), a precursor for the development of diabetes and heart disease. It is hypothesized that restricting dietary fructose intake results in reduced circulating blood lipid levels, increased satiety hormones and reduced inflammatory mediators and improved overall cardio-metabolic health.
Eligibility
Inclusion Criteria1
- Aged between 18 – 65 years at initial assessment. Males or female with BMI>30 [BMI = weight (kg)/ height (m)2]
Exclusion Criteria9
- Are currently on cholesterol lowering drugs e.g. Statins
- Are diabetic
- Pregnancy or lactation
- Are currently on anti-inflammatory drugs e.g. NSAIDs
- Are currently on fructose/sugar restricted diets
- Diagnosed with any gastrointestinal disorders
- Are currently on a weight loss program
- Undergone any surgical procedures for obesity
- Vegan diet
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Interventions
Subjects will be randomly assigned to the intervention diet (fructose restricted diet) which they will consume for 6 weeks. Participants will consume less than 50 gram fructose per day. At each visit, participants will receive a 30 - 45 minutes consultation with a qualified dietitian. There will be four visits. One at each of the following time points: Baseline, then weeks 6, 10 and 16. Subjects will be randomly assigned to either the intervention diet (fructose restricted diet) or the control diet (usual diet), which they will consume for 6 weeks. After a 4 week washout period, they will then consume the alternate diet for 6 weeks.
Locations(1)
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ACTRN12612000172808