RecruitingACTRN12612000172808

Does dietary fructose restriction improve cardio-metabolic health in obesity?

Does dietary fructose restriction improve plasma lipids, satiety hormones and inflammation in obesity?


Sponsor

The University of Newcastle

Enrollment

42 participants

Start Date

Feb 29, 2012

Study Type

Interventional

Conditions

Summary

Consumption of high fructose diets have been shown to contribute to the rising incidence of obesity worldwide. Increased fructose intake has been associated with many of the components of metabolic syndrome (insulin resistance, elevated waist circumference, dyslipidaemia, and hypertension), a precursor for the development of diabetes and heart disease. It is hypothesized that restricting dietary fructose intake results in reduced circulating blood lipid levels, increased satiety hormones and reduced inflammatory mediators and improved overall cardio-metabolic health.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether cutting back on fructose (a type of sugar found in many processed foods and drinks) can improve heart health and metabolism in people who are obese. High fructose diets have been linked to obesity, high cholesterol, high blood pressure, and diabetes risk. Participants will follow a low-fructose diet for a set period and researchers will measure blood fats, hunger hormones, and markers of inflammation. You may be eligible if: - You are between 18 and 65 years old - You are male or female with a BMI over 30 (obese) - You are not currently on a weight-loss program You may NOT be eligible if: - You are currently taking cholesterol-lowering medications (e.g., statins) - You have been diagnosed with diabetes - You are pregnant or breastfeeding - You are currently taking anti-inflammatory medications (e.g., NSAIDs) - You are already following a fructose-restricted or sugar-restricted diet - You have been diagnosed with a gastrointestinal disorder - You have had obesity surgery - You follow a vegan diet Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Subjects will be randomly assigned to the intervention diet (fructose restricted diet) which they will consume for 6 weeks. Participants will consume less than 50 gram fructose per day. At each vis

Subjects will be randomly assigned to the intervention diet (fructose restricted diet) which they will consume for 6 weeks. Participants will consume less than 50 gram fructose per day. At each visit, participants will receive a 30 - 45 minutes consultation with a qualified dietitian. There will be four visits. One at each of the following time points: Baseline, then weeks 6, 10 and 16. Subjects will be randomly assigned to either the intervention diet (fructose restricted diet) or the control diet (usual diet), which they will consume for 6 weeks. After a 4 week washout period, they will then consume the alternate diet for 6 weeks.


Locations(1)

Australia

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