Obesity Clinical Trials

1,223 recruiting

Obesity Trials at a Glance

1,312 actively recruiting trials for obesity are listed on ClinicalTrialsFinder across 6 cities in 70 countries. The largest study group is Not Applicable with 622 trials, with the heaviest enrollment activity in Houston, New York, and Chicago. Lead sponsors running obesity studies include Eli Lilly and Company, Norwegian University of Science and Technology, and University of Colorado, Denver.

Treatments under study

About Obesity Clinical Trials

Looking for clinical trials for Obesity? There are currently 1,223 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Obesity trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Obesity clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 1,312 trials

Recruiting

Investigating the Impact of Obesity on Pubertal Development in Girls

ObesityNormal PhysiologyPuberty
National Institute of Environmental Health Sciences (NIEHS)150 enrolled1 locationNCT02583646
Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

ObesityCardiomyopathyLi-Fraumeni Syndrome+3 more
National Heart, Lung, and Blood Institute (NHLBI)5,000 enrolled3 locationsNCT01143454
Recruiting

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

ObesityCardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)200 enrolled1 locationNCT01927783
Recruiting

Diabetes and Heart Disease Risk in Blacks

ObesityCardiovascular DiseasesHypertension+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00001853
Recruiting

Validation of Energy Expenditure Measures Study

HealthyObesity Prevention
University of Leipzig34 enrolled1 locationNCT07155564
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

Obesity
Kailera1,200 enrolled32 locationsNCT07284979
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes

Obesity With DiabetesOverweight With Diabetes
Kailera1,700 enrolled37 locationsNCT07284901
Recruiting
Phase 3

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

ObesityOverweight
Kailera1,800 enrolled33 locationsNCT07284875
Recruiting
Phase 2

Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment

ObesityWeight LossEating+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)148 enrolled1 locationNCT00739362
Recruiting

Children s Growth and Behavior Study

ObesityHealthy VolunteersEating Behaviors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1,500 enrolled1 locationNCT02390765
Recruiting
Not Applicable

Adaptation of Human Brown Adipose Tissue to Calorie Restriction

Obesity and Overweight
Universidad de Granada30 enrolled1 locationNCT06878989
Recruiting
Not Applicable

Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV

ObesityHIV-1-infection
University College Dublin80 enrolled1 locationNCT04174755
Recruiting
Phase 3

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Obesity
Novo Nordisk A/S400 enrolled82 locationsNCT07481630
Recruiting

Physical and Behavioral Traits of Overweight and Obese Adults

ObesityHealthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00428987
Recruiting
Early Phase 1

Tirzepatide in Obesity-Driven Endometrial Cancer

Endometrial CancerObesity
UNC Lineberger Comprehensive Cancer Center20 enrolled1 locationNCT07065552
Recruiting
Not Applicable

Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

ObesityWeight Loss
University of Colorado, Boulder84 enrolled1 locationNCT06776081
Recruiting
Not Applicable

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

ObesityInsulin ResistanceMuscle Weakness+2 more
University of Colorado, Denver70 enrolled1 locationNCT06129110
Recruiting
Not Applicable

Dyad Plus Effectiveness/Feasibility

Weight LossPediatric ObesityFamily and Household+2 more
Wake Forest University Health Sciences90 enrolled1 locationNCT04036331
Recruiting

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

ObesityInsulin ResistanceHyperinsulinism+2 more
Ali Chappell150 enrolled1 locationNCT05950282
Recruiting
Not Applicable

DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass

Weight GainObesity, Morbid
St. Antonius Hospital150 enrolled8 locationsNCT04894838