Obesity Clinical Trials

1,476 recruitingLast updated: June 6, 2026

There are 1,476 actively recruiting obesity clinical trials across 74 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Obesity Trials at a Glance

1,476 actively recruiting trials for obesity are listed on ClinicalTrialsFinder across 6 cities in 74 countries. The largest study group is Not Applicable with 717 trials, with the heaviest enrollment activity in Houston, New York, and Chicago. Lead sponsors running obesity studies include Eli Lilly and Company, Novo Nordisk A/S, and Norwegian University of Science and Technology.

Treatments under study

About Obesity Clinical Trials

Looking for clinical trials for Obesity? There are currently 1,275 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Obesity trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Obesity clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 1,476 trials

Recruiting

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

ObesityCardiovascular Disease
National Heart, Lung, and Blood Institute (NHLBI)200 enrolled1 locationNCT01927783
Recruiting
Not Applicable

New Heart Imaging Techniques to Evaluate Possible Heart Disease

ObesityHealthyDiabetes+2 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)4,000 enrolled1 locationNCT01399385
Recruiting
Not Applicable

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

ObesityOverweight
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)42 enrolled1 locationNCT06325722
Recruiting

Diabetes and Heart Disease Risk in Blacks

ObesityCardiovascular DiseasesHypertension+1 more
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,000 enrolled1 locationNCT00001853
Recruiting

Children s Growth and Behavior Study

ObesityHealthy VolunteersEating Behaviors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1,500 enrolled1 locationNCT02390765
Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

ObesityCardiomyopathyLi-Fraumeni Syndrome+3 more
National Heart, Lung, and Blood Institute (NHLBI)5,000 enrolled3 locationsNCT01143454
Recruiting
Phase 2

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

ObesityOverweight
Kailera320 enrolled19 locationsNCT07497880
Recruiting
Phase 3

A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

ObesityOverweight
Eli Lilly and Company600 enrolled35 locationsNCT07357415
Recruiting
Phase 3

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

ObesityOverweight
Eli Lilly and Company1,035 enrolled159 locationsNCT07282600
Recruiting
Phase 2Phase 3

Weight Management Plus LNG-IUS/Megestrol Acetate in Endometrial Atypical Hyperplasia

Overweight and ObesityAtypical Endometrial HyperplasiaFertility Issues
Xiaojun Chen172 enrolled1 locationNCT05316493
Recruiting
Phase 2

A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight

Overweight or Obesity and Elevated Liver Fat
Amgen180 enrolled22 locationsNCT07441252
Recruiting
Phase 3

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

ObesityOverweight
Eli Lilly and Company900 enrolled180 locationsNCT07392190
Recruiting
Phase 3

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

ObesityOverweight
Eli Lilly and Company1,980 enrolled169 locationsNCT07321886
Recruiting
Phase 3

Phase III Study of HRS-7535 for Hypertension With Overweight or Obesity

Hypertension With Overweight or Obesity
Shandong Suncadia Medicine Co., Ltd.648 enrolled2 locationsNCT07528027
Recruiting
Phase 1

A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants

ObesityOverweight
Hoffmann-La Roche40 enrolled1 locationNCT06982131
Recruiting
Phase 2

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

ObesityDiabetes Mellitus, Type 2Overweight
Eli Lilly and Company200 enrolled42 locationsNCT07215559
Recruiting
Phase 4

The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

ObesityMenopause Hot Flashes
Mayo Clinic40 enrolled1 locationNCT07218445
Recruiting
Phase 2

Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity

ObesityAcute Lymphoblastic Leukemia
St. Jude Children's Research Hospital20 enrolled1 locationNCT07228741
Recruiting
Phase 3

A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

ObesityOverweightSleep Apnea, Obstructive
Eli Lilly and Company800 enrolled129 locationsNCT07369011
Recruiting
Phase 3

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

OsteoarthritisOverweight or Obesity
Eli Lilly and Company900 enrolled160 locationsNCT07353931