Effect of steroids on blood sugar levels and risk of heart disease in pituitary patients
Effect of glucocorticoid replacement dose on cardiovascular risk and postprandial blood glucose in hypopituitary patients
Dr Morton Burt
20 participants
Feb 25, 2011
Interventional
Conditions
Summary
This study aims to assess whether higher doses of steroids increase the risk of heart disease in pituitary patients. We hope that this study will increase the understanding of the effects of steroid replacement dose in patients with pituitary disorders. This information may influence what doses of steroid replacement are optimal for the long-term health of pituitary patients.
Eligibility
Inclusion Criteria3
- Hydrocortisone less than or equal to 20mg per day (or other glucocorticoid at equivalent dose)
- GC use for at least 6 months
- Age greater than or equal to 20 years
Exclusion Criteria5
- Atrial fibrillation
- Beta blocker medication
- Raynaud’s phenomenon
- Inability to provide written informed consent
- On treatment for diabetes
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Interventions
An open interventional study assessing the effect of increasing oral glucocorticoid dose on arterial stiffness, endothelial function and autonomic nervous system activity. Subjects will be studied on their usual oral glucocorticoid dose and then again after increasing their oral glucocorticoid dose to hydrocortisone equivalent 30 mg/day for 7 days. At each study visit, subjects will be studied before and after drinking an oral glucose load (75 g)
Locations(1)
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ACTRN12612000234819