RecruitingACTRN12612000234819

Effect of steroids on blood sugar levels and risk of heart disease in pituitary patients

Effect of glucocorticoid replacement dose on cardiovascular risk and postprandial blood glucose in hypopituitary patients

Sponsor

Dr Morton Burt

Enrollment

20 participants

Start Date

Feb 25, 2011

Study Type

Interventional

Conditions

Hypopituitarism Secondary adrenal insufficiency

Summary

This study aims to assess whether higher doses of steroids increase the risk of heart disease in pituitary patients. We hope that this study will increase the understanding of the effects of steroid replacement dose in patients with pituitary disorders. This information may influence what doses of steroid replacement are optimal for the long-term health of pituitary patients.

Eligibility

Sex: Both males and femalesMin Age: 20 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at whether higher doses of steroid (hydrocortisone) replacement therapy in patients with pituitary gland problems increase the risk of heart disease and affect blood sugar levels. Many people with pituitary disorders need to take steroids every day as replacement therapy because their body does not produce enough. This study will measure heart function and blood sugar markers to help doctors find the safest dose. You may be eligible if: - You are 20 years of age or older - You take hydrocortisone at a dose of 20 mg per day or less (or an equivalent dose of another steroid) - You have been taking glucocorticoid (steroid) replacement for at least 6 months You may NOT be eligible if: - You have atrial fibrillation (an irregular heart rhythm) - You take beta-blocker medications - You have Raynaud's phenomenon - You are unable to provide written informed consent - You are currently being treated for diabetes Talk to your doctor about whether this trial might be right for you.

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Interventions

An open interventional study assessing the effect of increasing oral glucocorticoid dose on arterial stiffness, endothelial function and autonomic nervous system activity. Subjects will be studied

An open interventional study assessing the effect of increasing oral glucocorticoid dose on arterial stiffness, endothelial function and autonomic nervous system activity. Subjects will be studied on their usual oral glucocorticoid dose and then again after increasing their oral glucocorticoid dose to hydrocortisone equivalent 30 mg/day for 7 days. At each study visit, subjects will be studied before and after drinking an oral glucose load (75 g)

Locations(1)

Australia

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ACTRN12612000234819

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