Effect of 0.5% ketorolac tromethamine eye drop temperature on ocular comfort
For healthy adults aged 18 to 45 years, will refrigeration of 0.5% ketorolac tromethamine eye drops, compared to room temperature ketorolac tromethamine eye drops, improve subjective ocular comfort?
University of New South Wales
40 participants
Jul 1, 2012
Interventional
Conditions
Summary
The use of topical ocular non-steroidal anti-inflammatory drugs (NSAIDs) has been limited by the common side effects of burning and stinging. It has been reported that lowering the temperature of lubricant eye drops results in improved ocular comfort. This research project is to determine if refrigeration of 0.5% ketorolac tromethamine prior to administration improves patient tolerability of the commercially available preparation. These findings may lead to an improved method of delivery that will reduce the adverse effect profile of topical NSAIDs, increase patient compliance and influence future prescribing trends.
Eligibility
Inclusion Criteria1
- Healthy adults aged 18-45 years
Exclusion Criteria1
- No ocular surface disease, no contact lens wearers
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Interventions
1 drop of refrigerated (at approximately 4 degrees Celsius) 0.5% ketorolac tromethamine will be administered in one eye of the subject.
Locations(1)
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ACTRN12612000296831