The use of tranexamic acid to reduce blood loss during and after cesarean section
Tranexamic acid for prevention of postpartum hemorrhage in women undergoing elective cesarean section
Faculty of Medicine,Assiut University
700 participants
Aug 3, 2011
Interventional
Conditions
Summary
Bleeding after delivery is still the leading cause of maternal deaths especially in low resourced countries. Rates of delivery by cesarean section are increasing.One in three to four women are delivered by cesarean section.This trial is looking for new strategies to reduce blood loss after delivery by cesarean section.Tranexamic acid is a drug which prevents or delays lysis of blood clots after its formation .The formation of blood clot at the site of placental separation inside the uterus is an important mechanism to prevent bleeding after placental separation.This randomized controlled trial aims to evaluate the effectiveness and safety of tranexamic acid given to women at cesarean section.
Eligibility
Inclusion Criteria1
- All pregnant women with single fetus planned to have elective cesarean section at greater than 36wks gestation
Exclusion Criteria8
- History of medical disorders.
- Preclampsia.
- Antepartum hemorrhage.
- History of thromboembolic disorders.
- Polyhydramnios.
- Macrosomia.
- History of sensitivity to Tranexamic acid.
- Patients taking anticoagulant therapy.
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Interventions
Tranexamic acid (1gm)will be given slowly intravenously over 10 minutes before elective cesarean section
Locations(1)
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ACTRN12612000313831