RecruitingACTRN12612000339853

Non-invasive cerebellar stimulation for focal dystonia

Focal Dystonia treated using transcranial direct current stimulation compared to sham stimulation on neurophysioloigcal and functional measures


Sponsor

Lynley Bradnam

Enrollment

16 participants

Start Date

Mar 20, 2012

Study Type

Interventional

Conditions

Summary

The purpose of the study is to assess whether noninvasive stimulation of the cerebellum (base of the brain) can improve the symptoms of primary focal dystonia. Dystonia is a movement disorder that may be expressed, in part, due to dysfunction of motor networks in the brain including the cerebellum. There are few treatments currently available. If stimulating this region improves dystonia then it has potential to be used as a therapeutic intervention in the future.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether non-invasive brain stimulation of the cerebellum (the part of the brain at the back of the head that controls movement) can reduce symptoms of focal dystonia. Focal dystonia is a neurological movement disorder that causes uncontrollable muscle contractions in a specific part of the body, such as the hand or neck. The stimulation techniques used (TMS and tDCS) are painless and involve no surgery. Participants will attend several sessions to receive brain stimulation and have their movement tested before and after. You may be eligible if: - You are 18 years of age or older - You have been diagnosed with primary focal dystonia by a neurologist - You have no contraindications to TMS or tDCS (e.g., no head injury, epilepsy, or implanted devices) - You do not have any other neurological or musculoskeletal disorder affecting the affected area You may NOT be eligible if: - You have contraindications to TMS or tDCS (head injury, epilepsy, pacemaker or other implanted devices) - You have another musculoskeletal or neurological condition affecting the dystonic area - Your dystonia is secondary to another condition (e.g., stroke, Parkinson's disease) - You have generalised dystonia (affecting the whole body) Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Transcranial Direct Current Stimulation (TDCS) is a painless form of non-invasive brain stimulation. It is proposed to work by polarising brain tissue beneath the stimulating electrodes. Usually appli

Transcranial Direct Current Stimulation (TDCS) is a painless form of non-invasive brain stimulation. It is proposed to work by polarising brain tissue beneath the stimulating electrodes. Usually applied over the motor cortex, TDCS can either increase (anodal) or suppress (cathodal) excitability depending on electrode configuration. In this study, TDCS will be applied over the cerebellum. The current will be applied at 2mA for 20 minutes in three separate sessions, one week apart. The order of the sessions will be randomised. Two sessions will be cathodal, andodal and sham session. The randomisation order and the intervention will be applied by an independent investigator. Investigators who are collecting and analysing data will remaind blinded until the end of the study period.


Locations(1)

Australia

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