Not Yet RecruitingPhase 3Phase 4ACTRN12612000377831

Role of probiotics in improving post-colonoscopy symptoms and earlier return of normal bowel function

Role of oral probiotics in improving post-colonoscopy symptoms and earlier return of normal bowel function in patients undergoing colonoscopy after full mechanical bowel preparation


Sponsor

Dr Timothy Slack

Enrollment

200 participants

Start Date

May 1, 2012

Study Type

Interventional

Conditions

Summary

Mechanical bowel preparation causes a marked imbalance in the colonic microflora. This altered microflora may play a significant role in post-preparation symptoms and delay in return of the normal bowel function for that patient. AIM Evaluate the benefit of probiotic use, and associated restoration of the balance of intestinal microflora, for patients undergoing colonoscopy after mechanical bowel preparation. METHODS Prospective double-blinded randomised control trial. Use of probiotics vs placebo in the setting of patients who have undergone full mechanical bowel preparation and colonoscopy A commercially available probiotic or placebo at recommended daily dose for 7 days after the procedure END POINTS Evaluation of post-colonoscopy symptoms - Abdominal pain - Time taken for patient bowel function to return to normal (the usual bowel habit for them)


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria1

  • A patient who has completed full mechanical bowel preparation for a colonoscopy

Exclusion Criteria2

  • Failure to complete full mechanical bowel preparation
  • Enema preparation only for a flexible sigmoidoscopy

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Interventions

High Potency Probiotic Capsules containing Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07, once daily for 7 days post-colonoscopy

High Potency Probiotic Capsules containing Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07, once daily for 7 days post-colonoscopy


Locations(1)

Australia

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ACTRN12612000377831