Capsule endoscopy in the detection of small bowel neoplasias in patients with Lynch syndrome

The cumulative risk of small bowel neoplasias in patients with Lynch syndrome (LS) is of 4% (100 times higher than that of the normal population). Small bowel surveillance in patients with LS is not recommended in surveillance guidelines. Recent data from a study with a small number of patients capsule endoscopy detected small bowel neoplasias in 8,5% of asymptomatic patients with LS. We intend to perform a prospective observational uncontrolled study in asymptomatic LS patients older than 40 years. The main endpoint of the study is to access the prevalence of small bowel neoplasias using capsule endoscopy. All capsules will be read independently by two observers. All lesions detected will be evaluated by the two observers and a consensus will be reached. All patients with lesions considered to be relevant and related to the LS (polyps or tumours) will be submitted to double balloon endoscopy to evaluate the lesion and to obtain a specimen for histological examination.