Does exogenous glucose-dependent insulinotropic polypeptide (GIP) effect gastric emptying and glycaemic response to small intestinal nutrient in critically ill patients?

This study is looking at whether a gut hormone called GIP (glucose-dependent insulinotropic polypeptide) can lower blood sugar levels and affect how quickly the stomach empties in critically ill patients who are on a breathing machine. Managing blood sugar is very important in intensive care, and researchers are exploring whether GIP infusions might be a useful tool for this. You may be eligible if: - You are between 18 and 80 years old - You are on a mechanical ventilator in an intensive care unit - You are receiving or suitable to receive nutrition through a tube that goes past the stomach - You are expected to remain on the ventilator for at least 48 hours You may NOT be eligible if: - You have a history of diabetes - You are pregnant - Your hemoglobin level is below 80 g/L - There is a medical reason you cannot receive tube feeding - You have had previous surgery on your small intestine - You have had any gastrointestinal surgery during this hospital stay Talk to your doctor about whether this trial might be right for you.