The Glucose Tolerance Test Study

Incretins are hormones that are produced in the intestine in response to food. The major increton is GLP-1 which directly stimulates the pancreas to produce insulin. The incretin effect is responsible for the greater insulin secretion seen after oral glucose intake compared to intravenous glucose. we postulate that after meal insulin changes are responsible for the reduction in circulating inflamatory marker IL-6 concentrations after an oral glucose tolerance test. If this is correct we believe that when the same amount of glucose is adminitered intravenously, due to a reduced insulin response, the after food decrease in IL-6 will be lessened.