Outcome of allergen specific immunotherapy in asthmatic children
Long-term clinical and immunological effect of sublingual and subcutaneous immunotherapy in dust mite allergic asthma/rhinitis children: 3 years prospective randomized controlled trial
Marmara University BAPKO
50 participants
Mar 1, 2007
Interventional
Conditions
Summary
randomized controlled open trial of children with mild persistant asthma, HDM sensitized were included. All evaluated at baseline 1st and 3rd years with clinical status, bronchial hyperreactivity and immunological parameters
Eligibility
Plain Language Summary
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Interventions
1. sublingual immunotherapy (SLIT)+standard pharmacotherapy (SP) patients receive SLIT as 5 sublingual droplets three times a week for 3 years (Dermatophagoides pteronyssinus and pharinea %50 mix) after following an induction phase for 1 month of slowly increasing dosing schedule reaching the maintenance dose mentioned above with the same preparation 1st dose is supervised by the physician and the rest is ingested by patient at home 2. subcutaneous immunotherapy (SCIT)+standard pharmacotherapy SCIT is received by subcutaneous injection at the hospital by the physician once a month for 3 years (Dermatophagoides pteronyssinus and pharinea %50 mix) following a weekly injection (for 3 months) of increasing doses of allergen. a)starting dose of SCIT 0.1 ml of 100u/ml b) maintenance dose of SCIT 1 ml of 100000u/ml of allegen injected every child is supervised by a physician following the injection for half an hour
Locations(1)
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ACTRN12612000555853