Comparative evaluation of isobaric ropivacaine (0.75%) with the adjuvants - clonidine and dexmedetomidine administered intrathecally in adult patients undergoing infra-umbilical surgeries
safdarjung hospital
90 participants
Apr 1, 2012
Interventional
Conditions
Summary
In this randomized double blind prospective clinical study we plan to evaluate the efficacy of adding Clonidine (30mcg), Dexmedetomidine (5mcg) or isotonic saline to 0.75% isobaric Ropivacaine for administration of subarachnoid lumbar block in infra-umbilical surgical procedures with regard to characteristics of sensory and motor block and observation of any side effects.
Eligibility
Inclusion Criteria4
- Patients scheduled to undergo elective infra-umbilical surgery
- ASA grades 1 and 2
- height : 150 to 180 cms
- Duration of surgery not exceeding 2 1/2 hours
Exclusion Criteria16
- Patient refusal
- ASA grades 3 and 4
- Contraindications to spinal anaesthesia (absolute and relative)
- Patients with the following cardiovascular disorders:
- Heart rate < 55 beats/min
- Patients on antihypertensive drug therapy
- Those on heparin therapy, aspirin and other anti-platelet drug therapy
- Hepatic and renal disorders
- Obesity
- pregnancy
- Psychosis, dementia and other co-operation disorders
- Peripheral neuropathy
- Demyelinating central nervous system disorders
- Disorders of spine eg. scoliosis
- Chronic analgesic usage
- Known hypersensitivity to drugs
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Interventions
In this randomized double blind prospective clinical study we plan to evaluate the efficacy of adding Clonidine (30mcg), Dexmedetomidine (5mcg) or isotonic saline to 0.75% isobaric Ropivacaine for administration of subarachnoid lumbar block in infra-umbilical surgical procedures with regard to characteristics of sensory and motor block and observation of any side effects. Each of these treatments will be given on just one occasion Thereare three groups. GROUP RS (Ropivacaine + Isotonic Saline) is the control group They will be administered 3.0ml of 0.75% isobaric Ropivacaine + 0.2ml of Isotonic Saline (total volume of injectate 3.2ml) GROUP RC (Ropivacaine + Clonidine) They will be administered 3.0ml of 0.75% isobaric Ropivacaine + 30mcg of Clonidine (0.2ml Inj. Clonidine; total volume of injectate 3.2ml) GROUP RD (Ropivacaine + Dexmedetomidine) They will be administered 3.0ml of 0.75% isobaric Ropivacaine + 5mcg of Dexmedetomidine (0.05ml of Dexmedetomidine diluted to 0.2ml in isotonic saline; total volume of injectate 3.2ml)
Locations(1)
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ACTRN12612000581864