Peak plasma propofol levels during endoscopy
Peak plasma propofol levels in endoscopy patients receiving a Propofol-only anaesthetic
Monash Medical Centre
10 participants
Sep 8, 2011
Interventional
Conditions
Summary
The peak plasma propofol levels of endoscopy patients (Derived mathematically from the 3 measurements) along with the context sensitive half time of propofol (determined by the length of infusion) will allow the researchers to determine the time taken for plasma propofol levels to drop below levels known to cause driving impairment and thus estimate how long it takes for patients to drive safely after receiving a propofol only anaesthetic.
Eligibility
Inclusion Criteria1
- Undergoing colonoscopy or gastroscopy
Exclusion Criteria1
- ASA 3 or 4
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Interventions
Patients will receive propofol-only anaesthesia using the intermittent bolus technique. Propofol will be administered through an intravenous cannula using the intermittent bolus technique (large loading bolus followed by small frequent boluses) which titrates dosage to adequate sedation. The anaesthetist looking after the patient will give a propofol-only anaesthetic as per his or her usual procedure. The timing and dosage of boluses will not be stipulated by the researchers. The loading dose is given immediately prior to commencing the endoscopy. Further boluses are given when deemed required by the anaesthetist.
Locations(1)
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ACTRN12612000797875