Sevoflurane aggravate minimal hepatic encephalopath in cirrhosis patients

This study is looking at how a type of anesthesia gas called sevoflurane affects brain function in patients who have liver cirrhosis (scarring of the liver). Some patients with cirrhosis have a condition called minimal hepatic encephalopathy, which causes subtle problems with thinking, coordination, and reaction time — even if they seem fine on the surface. Researchers want to know if using sevoflurane during surgery makes this condition worse, which could affect how safe patients are after their operation. You may be eligible if: - You have been diagnosed with liver cirrhosis based on medical tests or a liver biopsy - You are between 18 and 70 years old - You are scheduled for a planned (non-emergency) surgery - Your cirrhosis is mild to moderate (Child-Pugh class A or B, with a score of 9 or less) - You are classified as low surgical risk (ASA class 1 or 2) You may NOT be eligible if: - You are currently bleeding from your digestive tract - You already have obvious signs of brain problems (overt encephalopathy) - You have a known allergy to sedative medications - You have a significant lung disease - You have active neurological problems - You have severe liver disease (Child-Pugh class C) - You have current alcohol or drug dependency - You have a psychiatric illness - You have vision in only one eye - You have any cognitive (thinking) impairment Talk to your doctor about whether this trial might be right for you.