SuspendedPhase 1ACTRN12612000952842

Bioavailability of orally administered gamma-glutamylcysteine

Bioavailability study to determine whether a single oral dose of gamma-glutamylcysteine (GGC) sodium salt can transiently increase glutathione content of the white blood cells and brain tissue of healthy volunteers.

Sponsor

University of New South Wales

Enrollment

18 participants

Start Date

Mar 25, 2013

Study Type

Interventional

Conditions

This bioavailability trial represents an initial investigation in healthy volunteers to determine the potential of gamma-glutamylcysteine (GGC) to augment cellular glutathione levels. Glutathione depletion is associated with numerous age related disorders.

Summary

Gamma glutamylcysteine (GGC) is commonly found in many foods, such as garlic and whey, which are anecdotally associated with numerous health benefits. GGC can potentially be used by the body to synthesise the commonly termed “master antioxidant” glutathione, which is responsible for protecting our cells from oxidative stress and for the elimination of toxins. As we age our body’s capacity to produce sufficient glutathione progressively declines leaving us vulnerable to many age related diseases and disorders. In this study, we will investigate whether oral administered GGC can be of benefit in increasing the glutathione content in blood cells in young. mature and aged populations.

Eligibility

Sex: Both males and femalesMin Age: 20 YearssMax Age: 80 Yearss

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying: Bioavailability of orally administered gamma-glutamylcysteine. The study is looking for participants who are between 20 years and 80 years old. Both male and female participants may be eligible. You may be eligible if: - Aged 20 - 80 years, reasonable health, non-smoker, non alcoholic, not pregnant, and not surgically fitted with metal medical devices (e.g. pace makers, Cochlear implants) . - Healthy body weight [body mass index (BMI) 18.5 - 25 kg/m2]. You may NOT be eligible if: - Smokers, alcoholics, any illnesses requiring regular medication. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

On separate days with a one week washout, participants will receive double blinded single oral doses of gamma-glutamylcysteine (GGC) in the range of 250 mg to 4g (placebo control glucose) . Participants will range from 18 to 20 years, with the only exclusions being smokers, pregnancy, and metal medical implants (MRI). Glutathione levels will be monitored periodically for up to 7 hours following administration by the taking of blood samples (lymphocyte glutathione content) and/or by MRI/MRS (brain tissue content).

Locations(1)

NSW, Australia

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ACTRN12612000952842